A Novel Azopyridine-based Ru(Ⅱ) Complex with GSH-responsive DNA Photobinding Ability

来源 :第十一届全国物理有机化学学术会议 | 被引量 : 0次 | 上传用户：lcl427hjc

【摘要】

：

【作者】

：

Qian-Xiong Zhou Xue-Song Wang

【机构】

：

Technical Institute of Physics and Chemistry, Chinese Academy of Sciences,29 Zhongguancun East Road,

【出处】

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第十一届全国物理有机化学学术会议

【发表日期】

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2015年3期

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A novel azopyridine-based Ru(Ⅱ) complex [Ru(bpy)2(L1)2]2+ (bpy =2,2-bipyridine, L1 =4,4-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can be only activated after GSH reduction and visible light irradiation.

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A Novel Azopyridine-based Ru(Ⅱ) Complex with GSH-responsive DNA Photobinding Ability

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