DptP protein is required for exporting of daptomycin in Streptomyces roseosporus

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：zhangshuai5365

【摘要】

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【作者】

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Dan Zhang Yang Ye Yu He Shufang Liang

【机构】

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State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University/National

【出处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

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2018年10期

【关键词】

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Daptomycin dptP gene gene cluster proteome Streptomyces roseosporus

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　　Daptomycin(DAP),a cyclic lipopeptide produced by Streptomyces roseosporus(S.roseosporus),is a novel antibiotic against Gram-positive bacteria.The dptP gene locates upstream of the DAP gene cluster dpt,and its encoding protein shares a significant sequence similarity with Ded A family membrane proteins,which is required for growth or drug efflux.

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DptP protein is required for exporting of daptomycin in Streptomyces roseosporus

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