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  5. Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle Eas

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle Eas

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：dabingjiajia
【摘 要】
：
Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4-16.The nsp5 of the newly
【作 者】
：
Wu A Wang Y Zeng C Huang X Xu S Su C Wang M Chen Y Guo D 
【机 构】
：
State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan,PR China
【出 处】
：
第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
【发表日期】
：
2015年6期
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Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4-16.The nsp5 of the newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) was identified as 3CLpro and its canonical cleavage sites (between nsps)were predicted based on sequence alignment,but the cleavability of these cleavage sites remains to be experimentally confirmed and putative non-canonical cleavage sites (inside one nsp) within the pp1a/1ab awaits further analysis.
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