【摘 要】
:
精神分裂症(schizophrenia)是一种严重的慢性精神障碍,影响近1%的人口。给社会、家庭带来巨大的经济与精神负担。精神分裂症发病机制除了与遗传、环境、社会等因素有关外,多巴胺,谷氨酸和5-羟色胺系统功能障碍是精神分裂症病理生理的关键。目前为人们所认同的精神分裂症病因主要包括三种假说:多巴胺假说、5-羟色胺假说和谷氨酸假说。
【机 构】
:
中国卫生部核医学重点实验室,江苏省原子医学研究所
【出 处】
:
2014第五届国际神经科技大会暨2014首届国际高科技针灸和中西医结合大会
论文部分内容阅读
精神分裂症(schizophrenia)是一种严重的慢性精神障碍,影响近1%的人口。给社会、家庭带来巨大的经济与精神负担。精神分裂症发病机制除了与遗传、环境、社会等因素有关外,多巴胺,谷氨酸和5-羟色胺系统功能障碍是精神分裂症病理生理的关键。目前为人们所认同的精神分裂症病因主要包括三种假说:多巴胺假说、5-羟色胺假说和谷氨酸假说。
其他文献
Neuronal Calcium Sensor (NCS) proteins comprise a family of proteins that determine response to calcium fluctuations.Their role in normal physiological functions such as photo/visual transduction and
Purpose: The aim of the present study is to determine whether Tamoxifen causes attenuation of traumatic brain injury (TBI) induced depression-like behavior induced by fluid percussion injury (FPI).Mat
Alzheimers disease (AD) is a devastating neurodegenerative disease for which no cure (other than palliative) exists.The search for cure demands knowledge of the early pathological changes-critical nec
Recently there has been increased interest in neural biomarkers and the understanding the brains functional connectivity across local and tong-range networks.While structural and functional connectivi
New research criteria have been developed that define three principal phases in Alzheimers disease: Preclinical, Mild Cognitive Impairment, and dementia.These criteria consider the cognitive and bioma
Transient receptor potential (TRP) ion channels have been extensively investigated over the past few years and they are being ardently pursued as targets for drug discovery.Several factors make TRP io
There has been a resurgence of interest in peptide pharmaceuticals recently as they have an advantage of potency, selectivity and less toxicity compared with small-molecule therapeutics.In addition, t
Chronic subdural hematoma (CSDH) is resulted from inflammation and the disturbance of angiogenesis.Besides down regulating the lipid, atorvastatin is pleotropic in increasing the effective angiogenesi
In current drug discovery pipeline, in vitro biochemical and cell-based screening assays have been widely used before the pharmacological validation tests on in vivo animal models.Nevertheless, the lo
目的:比较在重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓前或后分别联合依达拉奉治疗急性脑梗死的有效性和安全性.方法:回顾性分析江苏省卒中研究协作组织共5家医院行rt-PA(0.gmg/kg)静脉溶栓联合依达拉奉治疗的急性脑梗死(发病0.050).②A组溶栓后24h、出院时NIHSS评分较B组有显著改善(P=0.004、0.038);3月后好转率(mRS评分0-1)A组61.1%、B组36.4%,