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  5. The L-type calcium channel antagonist isradipine reduce iron accumulation in the substia nigra in MP

The L-type calcium channel antagonist isradipine reduce iron accumulation in the substia nigra in MP

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：tigernone
【摘 要】
：
Parkinsons disease(PD)is pathologically characterized by the progressive loss of dopaminergic neurons in the substantia nigra(SN).Studies in animal models of PD suggest that Cav1.3 L-type Ca2+channels
【作 者】
：
Qimin Wang Junxia Xie Zegang Ma 
【机 构】
：
Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurol
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
L-type Cav1.3 calcium channel MPTP Parkinson's disease Isradipine Dopaminer 
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　　Parkinsons disease(PD)is pathologically characterized by the progressive loss of dopaminergic neurons in the substantia nigra(SN).Studies in animal models of PD suggest that Cav1.3 L-type Ca2+channels may contribute to the neurodegenerative process by increasing Ca2+entry.The L-type calcium channel antagonist isradipine has the highest affinity for Cav1.3 L-type channels.
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