To observe the morphologic characteristics of hippocampus on 10 month-aged APP/PS1 double transgenic mouse,then verification weather this model can simulate the pathologic change of AD in this age.
Objective: Deep brain stimulation(DBS)is a neural modulation therapy which uses electrodes to deliver electrical stimulation onto specific nuclei or brain areas in human deep brain with the purpose of
Parkinsons disease(PD)has become a social problem in China,seriously affecting population health and life quality and inhibiting economic development.However,no effective treatment for PD is available
Objective Alzheimers disease(AD)is a progressive and degenerative disorder accompanied by cognitive impairment,but effective strategies against AD are currently not available.Epidemiological studies h
Objective Cathepsin C(dipeptidyl peptidase I,DPPI)is a lysosomal cysteine proteinase,which belongs to papain superfamily.Cathepsin C can promote production of chemokines and cytokines by activating se
Minocycline is a broad-spectrum tetracycline antibiotic.A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models of neurological diseases.H