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  5. Suppression of signal transducer and activator of transcrlptlon-3 signaling cascade by zerumbone inh

Suppression of signal transducer and activator of transcrlptlon-3 signaling cascade by zerumbone inh

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：ICE867200WXM
【摘 要】
：
Aim: Signal transducer and activators of transcription 3 (STAT3) has been linked to the deregulated proliferation, survival, and angiogenesis in renal cell carcinoma (RCC).In this study we investigate
【作 者】
：
Muthu K SHANMUGAM Rajendran PERAMAIYAN Feng LI Siveen KODAPPULLY SIVARAMAN Kwang Seok AHN Alan Prem KUMAR Gautam SETHI 
【机 构】
：
Department of Pharmacology,Yong Loo Lin School of Medicine,National University of Singapore,117597 S
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
STAT3 JAK2 zerumbone renal cell carcinoma apoptosis 
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Aim: Signal transducer and activators of transcription 3 (STAT3) has been linked to the deregulated proliferation, survival, and angiogenesis in renal cell carcinoma (RCC).In this study we investigated whether zerumbone, a sesquiterpene,obtained from the plant Zingiber zerumbet Smith exerts its anticancer effect through the modulation of STAT3 activation pathway.
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