ATM相关论文
研究背景血管钙化是心血管事件发生的独立危险因素,是钙磷在血管壁异常沉积的过程。血管平滑肌细胞(Vascular smooth muscle cells,......
目的:探讨共济失调毛细血管扩张突变基因(ataxia-telangiectasia mutated gene, ATM)单核苷酸多态性(SNP)rs189037和rs609261两个位点......
第一部分AMPKα是否参与细胞内DNA双链断裂修复过程[目的]研究AMPKα是否参与卵巢癌细胞DNA双链断裂修复。[方法]本部分实验分为以......
NFkappaB是转录因子家族中极为重要的一员,NFkappaB家族中有五个成员:RelA(p65),RelB,c-Rel,p50/p105(NF-kB1), p52/p100(NF-kB2),它可以通过......
血管平滑肌细胞(vascular smooth muscle cells,VSMCs)位于血管壁的中层,其主要功能是收缩,且增殖速率极低。VSMCs的异常增殖和迁移......
干细胞诱导过程中基因组不稳定会降低其重编程效率,阻碍干细胞技术发展。研究重编程过程中的DNA断裂,可以为提高干细胞诱导效率和......
Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage,inhibiting ATM/SOG1-mediated DNA
Arabidopsis methylation elevated mutant 1 (mem1)mutants have elevated levels of global DNA meth-ylation.In this study,su......
随着计算机技术的不断发展和进步,智能视频监控受到了人们的广泛关注.整合技术内容和技术要点,搭建更加合理的技术管理平台,从而实......
目的:各种来自机体内外环境中的损伤因素,如机体代谢产生的活性氧、紫外线、电离辐射、基因毒性药物等均能引发基因组DNA的结构性......
第一部分移动监测平台的建立对前列腺癌诊断随访的初步研究目的:开发一种动态监测前列腺癌(PCa)风险的应用程序,以评估患者前列腺癌......
本文充分利用电力系统的通信网络资源,结合ATM、SONET/SDH、XDSL等技术,提出了东莞电力营销数据通信网的建设方案.实现了对全市营......
本文以传统控制理论和Smith原则为关键工具对高速通信网络设计了一种改进的基于Smith原则的计算机高速通信网络的拥塞控制方案,对......
文章阐述了广域网面临的主要问题及下一代广域网的基本要求,给出了广域网的4种技术解决方案:弹性分组环、以太网、ATM和POS技术,分......
ATM和IP均可用作视频传输,正像前几年的IP和ATM之争一样,目前视频业务的传输选择ATM或者IP来进行适配出现了相应的争论.本文从一些......
目的 共济失调-毛细血管扩张突变基因(Ataxia telangiectasia-mutated gene,ATM)是直接感受DNA 双链断裂损伤并引起诸多DNA 损伤信......
Objective To detect the expression status of ATM in T lymphoblastic lymphoma.To testify the tumor suppressor function of......
目的 目前鼻咽癌治疗首选放疗并辅助铂类化疗,但依然有部分患者出现局部复发及远处转移,找到新的低毒性放射增敏药物至关重要。利鲁......
目的 白血病的发生发展通常认为与白血病干细胞(Leukemic Stem Cells,LSCs)的存在密不可分。共济失调-毛细血管扩张突变基因(ataxi......
Formaldehyde influence DNA damage repair process through PARP-1 pathway in the human bronchial epith
OBJECTIVE To investigate the cellular pathways or proteins involved in DNA damage repair induced by low concentration fo......
A hormesis-like effect of 1800 MHz radio frequency electromagnetic fields on DNA damage in mouse emb
Radiofrequency electromagnetic fields(RF-EMFs)have been classified by the International Agency for Research on Cancer as......
The biological effects of chronic radiation exposure are far from complete.With the aim of better understanding the biol......
HDAC2 augments DNA damage-mediated cell death of human osteosarcoma cells through the stimulation of
To overcome the serious chemo-resistant phenotype of the advanced cancers,it is urgently required to precisely understan......
XRCC4-deficient (XRCC4-/-) cells generated by a gene targeting exhibit a lower survival rate and a higher frequency of c......
研究背景 宫颈癌是女性常见的恶性肿瘤,发病率在女性所有恶性肿瘤中居第4位,但是在部分发展中国家,由于宫颈癌筛查不到位,其发病率......
目的:研究DNA 损伤修复通路相关分子ATM 及其下游分子在口腔白斑和鳞癌中的表达水平,初步确定ATM 和γH2AX 在口腔白斑癌变过程中的......
Immunohistochemical analysis reveals frequent tumoral loss of ATM protein expression in lung and col
Introduction: Somatic mutations in the Ataxia-telangiectasia mutated (ATM) gene have been identified in a range of cance......
会议
The overlapping, yet independent, functions of ATM, ATR and p53 in coordinating cell cycle transitio
Activation of the DNA-damage response (DDR) can enable cancer cells to resist the lethal effects of genotoxic cancer the......
Ataxia telangiectasia mutated (ATM), a high molecular weight PI3K-family kinase,is a predominantly nuclear protein invol......
The primary cause of A-T is ATM mutations.The ATM protein is a multifunctional,homeostatic protein kinase with a major r......
The ATM protein kinase is implicated in the DNA damage response and in sensing DNA double strand breaks.However, recent ......
ATM-mediated Chk1/2 and Cdc2 phosphorylation is Involved In Jaridonin-induced cell cycle arrest In h
Aims: Jaridonin, a novel diterpenoid from Rabdosia rubescens has been shown previously to inhibit proliferation of esoph......
NUCLEOLIN PARTICIPATES IN DNA DOUBLE-STRAND BREAK-INDUCED DAMAGE RESPONSE THROUGH MDC1-DEPENDENT PAT
H2AX is an important factor for chromatin remodeling to facilitate accumulation of DNA damage-related proteins at DNA do......
多年来的大量研究,已逐步完善了DNA修复途径的调控通路,这对于癌症的防治非常重要。毛细血管扩张性失调突变激酶(ATM)是DNA损伤信号......
冰桥(IceBridge)项目是美国航空航天局(NASA)自2009年开始的用激光测高技术(Airborne Topographic Mapper system,ATM)来监测极地......
ATM以其独特的优点受到人们的关注,其相关技术成为近几年研究的热点.流量控制技术是保证ATM网络可靠、安全、快速运行的关键.本文......
论述了数字图书馆的基本特征,着重对数字图书馆建设密切相关的两种高速宽带网络技术—ATM和千兆以太网进行了评介,并分析对比了这......
目的探究锌指结构E-box结合蛋白1(ZEB1)对胃癌细胞AGS放射敏感性的影响并探究其可能的作用机制。方法通过不同剂量(0、2、4、6、8 ......
目的 探讨p53和ATM基因缺失在慢性淋巴细胞白血病患者(CLL)中的预后价值.方法 采用间期荧光原位杂交(FISH)技术和p53、ATM基因的序......
共济失调性毛细血管扩张(AT)是由突变型AT(ATM)基因所引起,其突出特点是AT细胞辐射高敏感性.AT临床症状、ATM基因的定位、结构与功......
期刊
目的 研究渥曼青霉素(wortmannin,WM)对恶性胶质瘤的辐射增敏作用及机制.方法 采用10 μmol/L WM预处理人胶质瘤细胞U251 2 h,并给......
目的 探讨西妥昔单抗(C225)联合放疗对CNE-2裸鼠移植瘤Ku80和ATM的影响.方法 建立CNE-2裸鼠移植瘤模型,将48只裸鼠按随机数字表法......