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目的：探讨米索前列醇（ＭＰ）在足月妊娠引产中的最适剂量。方法：将９２例妊娠３８～４１＋周的正常孕妇有引产指征者，随机分为３组：Ａ组在阴道后穹窿放ＭＰ５０μｇ，每４ｈ加１次至临产；Ｂ组在阴道后穹窿放ＭＰ５０μｇ，４ｈ后放２５μｇ，如未临产，每２ｈ放２５μｇ１次至临产；Ｃ组在阴道后穹窿放ＭＰ２５μｇ，每２ｈ放１次至临产。结果：３组总有效率无明显差异，Ａ组引产成功率９０．６３％，Ｂ组成功率９０．００％，Ｃ组成功率９０．００％。３组宫缩异常发生率分别为Ａ组１８．７５％，Ｂ组与Ｃ组均为６．６７％。结论：阴道放置米索前列醇用于足月妊娠引产是安全、有效的引产方法，但Ｂ组的方案更适合于临床应用。
Objective: To investigate the optimal dose of misoprostol (MP) in induction of term pregnancy. Methods: Ninety-two pregnant women with gestational age ranging from 38 to 41 weeks were randomly divided into three groups: group A received MP50μg in the vaginal fornix and fasted once every 4h until labor; group B received MP50μg in vaginal fornix , After 4h put 25μg, if not labor, every 2h put 25μg 1 times to labor; group C in the vaginal fornix put MP25μg, put every 2h to labor. Results: There was no significant difference in the total effective rate between the three groups. The success rate of induction of labor in group A was 90.63%, the success rate of group B was 90.00% and the success rate of group C was 90.00%. The incidence of contractions in group 3 were 18.75% in group A and 6.67% in group B and C, respectively. Conclusion: Vaginal placement of misoprostol for induction of labor during term pregnancy is a safe and effective method of induction of labor. However, the B group is more suitable for clinical application.