不同配体修饰CdTe量子点对线粒体渗透转换孔的影响

来源 :中国化学会生物物理化学专业委员会第四届全国生物物理化学会议 | 被引量 : 0次 | 上传用户:kimimoomoo
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  量子点由于其优良的光电性质,近年来在生物标记、成像、电子器件等方面得到了广泛的应用。随着其应用的增多,有必要对其潜在的生物毒性做更多的了解。有研究表明,线粒体是量子点毒性的靶向细胞器之一,量子点可以损伤线粒体的形态及功能。本文以巯基丙酸(MPA)和巯基乙酸(TGA)为配体,采用水相合成法,合成了2 种粒径相近的CdTe 量子点,并研究比较了2 种量子点对线粒体渗透转换孔(MPTP)的影响。
其他文献
  The development of fluorescent tools with high fluorescence quality and efficient targeting is of great importance in immunoassay.Here we report combination
会议
  Single-walled carbon nanotubes(SWCNTs)are widely used in different areas especially the field of biomedicine as drug vehicles.However,large scale production
会议
  Circadian clocks are intrinsic,time-tracking systems that enable organisms to anticipate environmental changes and allow them to adapt their behavior and ph
会议
  The receptor mediated endocytosis of nanoparticles(NPs)is known to be size and shape dependent but regulated by membrane properties,like tension,rigidity an
会议
  Colicin A is a bacterial toxin which kills colicin-sensitive bacteria by forming a voltage-gated channel in the cytoplasmic membrane.The pore forming domain
会议
  Hsp70 is a conserved molecular chaperone which plays an indispensable role in regulating protein folding,oligomerization,and degradation in prokaryotic and
会议
  生物界面上蛋白质-蛋白质以及蛋白质-磷脂之间的相互作用直接决定蛋白质在生物膜上的结构、功能和宏观性质。但是分子间的相互作用是一种远程的、强度较弱的相互作用,在实
  The Escherichia coli molecular chaperone GroEL is an important nano-cage for protein folding.Using peptide substrates as mimetics of non-native proteins in
会议
  以荧光染料BODIPY 为母体,通过柔性碳链分别连接三乙胺、三苯基膦及F16,合成得到了三种线粒体靶向荧光探针。通过MTT、Confocal、FL 及流式细胞仪等方法检测,对比了其荧
  Biological thiols play pivotal roles in human physiology,such as cysteine(Cys),homocysteine(Hcy)and glutathione(GSH),design and synthesed the hight selectiv
会议