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  5. Compare the efficacy of inhaled budesonide and systemic methylprednisolone on systemic inflammation

Compare the efficacy of inhaled budesonide and systemic methylprednisolone on systemic inflammation

来源 :2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户：zhilong217
【摘 要】
：
目的 To compare the efficacy of inhaled budesonide and systemic methylprednisolone on systemic inflammation of AECOPD.方法 30 AECOPD patients were randomly divided into two group.Budesonide group(15 cases
【作 者】
：
XuejiaoSun 
【机 构】
：
Department of Respiratory Medicine,The First Affiliated Hospital of Guangxi Medical University
【出 处】
：
2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
【发表日期】
：
2016年4期
【关键词】
：
Chronic obstructive pulmonary disease exacerbation inhaled corticosteroid safety 
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　　目的 To compare the efficacy of inhaled budesonide and systemic methylprednisolone on systemic inflammation of AECOPD.方法 30 AECOPD patients were randomly divided into two group.Budesonide group(15 cases)were treated with inhaledbudesonide(3 mg Bid)； methylprednisolone group(15 cases)were treated with systemic methylprednisolone(methylprednisolone acetate injectable suspension 40mg Qd for three days and then methylprednisolone tablets 8mgBid).Observe symptoms,lung function,blood gas analysis and adverse effects of the patients in two groups.Peripheral bloodsamples were collected before and after treatment for 1 day,4 days and 7 days.Interleukin-8(IL-8)and TNF-α levels weredetermined by an enzyme linked immunosorbent assay(ELISA).Hs-CRP levels were detected by automatic biochemical analyzer.Western blotting was used to determine histone deacetylase 2(HDAC2)protein expression.
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