The autophagy-linked FYVE protein (ALFY) is a large multi-domain protein implicated in the selective degradation of ubiquitinated protein aggregates by autophagy (aggrephagy).ALFY interacts with the ubiquitin-binding autophagy receptor p62 and facilitates recruitment of the autophagic membrane through its binding to ATG5, GABARAP and phosphatidyl-inositol 3-phosphate [1-4].