【摘 要】
：
Autophagy is a major catabolic pathway for maintaining cell homeostasis through degradation and recycle of macromolecules and organelles.Autophagy can be ac
【机 构】
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Department of Physiology, University of Hong Kong, Hong Kong, China
【出 处】
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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
Autophagy is a major catabolic pathway for maintaining cell homeostasis through degradation and recycle of macromolecules and organelles.Autophagy can be activated under environmental stress conditions, including reactive oxygen species (ROS).TRPM2, a non-selective trans-membrane calcium channel, can be activated by ROS that, in turn, leads to intracellular Ca2+ increase through Ca2+ influx.It is well known that ROS regulates autophagy,and vice versa.Yet, the molecular mechanisms underlying the interplay between ROS and autophagy remain elusive.Here we studied the role of TRPM2-mediated Ca2+ influx in interplay between ROS and autophagy.
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