论文部分内容阅读
目的:研究重度子痫前期(PE)孕妇血清、胎儿脐血中内皮脂酶(EL)的表达及其与血脂代谢的关系,探讨EL在PE发病中的作用。方法:选取行剖宫产分娩的重度PE单胎孕妇30例为病例组,行剖宫产分娩的30例正常孕妇为对照组。ELISA法检测孕妇血清及胎儿脐血中的EL浓度;用全自动生化分析仪检测血脂浓度。分析EL浓度与血脂指标的相关性。结果:(1)与正常孕妇比较,重度PE组孕妇的血清三酰甘油(TG)浓度增高,高密度脂蛋白(HDL)浓度降低,动脉硬化指数(AI)增高,差异均显著(P=0.003)。重度PE组胎儿脐血中TG、总胆固醇(CHO)、低密度脂蛋白(LDL)及AI均显著高于对照组(P=0.000)。(2)重度PE组孕妇的血清EL浓度显著高于对照组(692.96ng/ml vs441.21ng/ml,P=0.000),而两组胎儿脐血中的EL浓度无显著差异。(3)孕妇血清EL浓度与TG浓度呈正相关(r=0.354,P=0.006),与HDL浓度呈负相关(r=-0.451,P=0.000)。结论:重度PE孕妇及胎儿脐血中均存在血脂异常,重度PE孕妇血清中EL浓度显著增高。提示EL影响血脂代谢,且其可能与PE的发病机制有关。
OBJECTIVE: To study the expression of endothelin (EL) in serum and fetal umbilical cord blood of patients with severe preeclampsia (PE) and its relationship with lipid metabolism, and to explore the role of EL in the pathogenesis of PE. Methods: Thirty cases of severe single PE pregnant women who were delivered by cesarean section were selected as the case group. Thirty normal pregnant women delivered by cesarean section were selected as the control group. ELISA method to detect serum and fetal cord blood of pregnant women EL concentration; automatic biochemical analyzer for detecting serum lipids. Analysis of the correlation between EL concentration and lipid profile. Results: (1) Serum triglyceride (TG), HDL and AI in pregnant women with severe PE were significantly higher than those in normal pregnant women (P = 0.003 ). TG, total cholesterol (CHO), low density lipoprotein (LDL) and AI in cord blood of severe PE group were significantly higher than those in control group (P = 0.000). (2) Serum EL concentrations of pregnant women in severe PE group were significantly higher than those in control group (692.96ng / ml vs441.21ng / ml, P = 0.000). There was no significant difference in EL concentration between the two groups. (3) There was a positive correlation between serum EL concentration and TG concentration in pregnant women (r = 0.354, P = 0.006), and negatively correlated with HDL concentration (r = -0.451, P = 0.000). Conclusion: There are dyslipidemia in both pregnant women with severe PE and fetal umbilical cord blood. EL concentrations in sera of pregnant women with severe PE are significantly increased. It is suggested that EL affects blood lipid metabolism and may be related to the pathogenesis of PE.