【摘 要】
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Background, Motivation and Objective Non-invasive transdermal delivery of drugs offers a number of advantages over conventional delivery methods. For the past twenty years considerable attention was p
【机 构】
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Guided Therapy Systems, Mesa, AZ, USA Ardent Soun
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Background, Motivation and Objective Non-invasive transdermal delivery of drugs offers a number of advantages over conventional delivery methods. For the past twenty years considerable attention was paid to ultrasound assisted delivery at relatively low frequency (20 KHz-3 MHz) and low acoustic intensity (<3w/cm2) requiring minutes to several hours to enhance delivery. The purported mechanism of action is associated with cavitation increasing drug diffusion through the stratum corneum and epidermis.
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