Granulocyte and monocyte apheresis in the treatment of ulcerative colitis the first multicenter stud

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户:qiaomy
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Background Patients with active ulcerative colitis (UC) have elevated and activated myeloid lineage leucocytes, notably the CD 14 (+)CD16(+) monocyte phenotype, which is a major source of tumor necrosis factor (TNF)-α.Hence selective depletion of these leucocytes by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn should alleviate inflammation and promote remission or at least enhance drug efficacy.However, hitherto studies have reported contrasting efficacy outcomes, which reflect patients demographic variables at entry.
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