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Aims As a critical event involved in the airway remodeling,epithelial-mesenchymal transition(EMT)of bronchial epithelial cells occurs in a range of respiratory disorders such as asthma and pulmonary fibrosis.Since protease-activated receptor-2(PAR2)is well documented to be implicated in airway disorders,little is known about its role in EMT so far.Our study was to determine the impact of PAR2 on EMT and illustrate the mechanisms underlying.