目的 Lung adenocarcinoma has one of the highest morbidity and mortality rate of any cancer worldwide.Our previous studieshave demonstrated that progesterone can inhibit lung adenocarcinoma A549 cells proliferation,improve chemo-sensitivity toGefitinib and inhibit migration and invasion in combination with Src inhibitor PP1 via a membrane progesterone receptormechanism.Long noncoding RNAs(lncRNAs)have been shown to play essential roles in some types of cancer； however,thecontributions of lncRNAs to progesterone-associated mechanisms in lung adenocarcinoma remain unknown.