无溶剂绿色高效合成色满酮类化合物研究

来源 :中国化学会第十三届全国有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户:mcusun
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  色满酮(Chromone)又称4-色满酮、苯并二氢吡喃-4-酮,是一种存在于生物体内的苯并杂环类次生代谢产物。色满类化合物在自然界分布广泛,许多生物的次生代谢产物中都含有其基本结构,说明这种结构对于有机体的生命活动具有至关重要的作用。目前为止,诸多植物、海洋生物中发现了色满酮及其苷类化合物,由于α,β-不饱和环酮或内酯极易与生物体内的含巯基的一些肽类(如谷光甘肽)和调节酶发生Michael加成以保持环的稳定性,从而影响这些酶的活性,发挥其抗癌、抗炎作用。因此寻找新的高效合成和修饰该类结构的化合物一直是药物研究的重要方向。
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