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  5. Prokaryotic expression of AAVR fusion proteins and the application for AAV preparation and character

Prokaryotic expression of AAVR fusion proteins and the application for AAV preparation and character

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：shmily8318
【摘 要】
：
As a prominent viral vector,adeno-associated virus(AAV)has been used for human gene therapy for more over three decades,however,its natural cellular receptor AAVR was discovered until recently.The pro
【作 者】
：
Mengtian CUI Dong YAN Yabin LU Wei DING 
【机 构】
：
Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Capital Medical Un
【出 处】
：
中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
【发表日期】
：
2018年10期
【关键词】
：
AAVR affinity chromatography ELISA streptavidin binding peptide (SBP) viral tite 
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　　As a prominent viral vector,adeno-associated virus(AAV)has been used for human gene therapy for more over three decades,however,its natural cellular receptor AAVR was discovered until recently.The protein coded by gene KIAA0319L demonstrated the property of binding various AAV serotypes with high affinity(150 nm Kd).
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