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  5. Rosuvastatin regulates the expression and activity of Krüppel-like transcription factor 2 in human u

Rosuvastatin regulates the expression and activity of Krüppel-like transcription factor 2 in human u

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：ansonliu
【摘 要】
：
Background Multiple evidences indicated that statins exhibit atheroprotective effects greater than those anticipated from LDL-lowering alone.Rosuvastatin has been reported to increase anticoagulants a
【作 者】
：
MA Qian YU Miao YANG Shi-wei JIA De-an ZHOU Yu-jie 
【机 构】
：
Capital Medical University Affiliated Beijing Anzhen Hospital and Beijing Institute of Heart,Lung an
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Multiple evidences indicated that statins exhibit atheroprotective effects greater than those anticipated from LDL-lowering alone.Rosuvastatin has been reported to increase anticoagulants and decrease procoagulants in human umbilical vein endothelial cells (HUVECs).KLF2 was strongly implicated to be a novel nuclear mediator of statin effects in endothelial cells.We hypothesized that rosuvastatin might induce the expression and activity of KLF2 in order to protect thrombosis.
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