Overactivation of NMDA receptor is a key event in excitotoxicity that induces a sudden intracellular.Ca2+ elevation and finally leads to cell apoptosis and necrosis and inhibition of the Ca2+ overload by blocking NMDA receptor can be neuroprotective.TRPC6 channel, one of the Ca2+-permeable nonselective cation channels, plays multiple important roles in neurite outgrowth, synapse formation and neuronal survival during neuronal development.However, little is known about the mechanisms of TRPC6-mediated neuroprotection and the relationship between TRPC6 channels and NMDA receptors.