【摘 要】
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Galectin-3(Gal-3)has been implicated in pancreatic ductal adenocarcinoma(PDAC),and its candidacy as a therapeutic target has been evaluated.Gal-3 is widely
【机 构】
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Glycochemistry & Glycobiology Lab,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,S
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Galectin-3(Gal-3)has been implicated in pancreatic ductal adenocarcinoma(PDAC),and its candidacy as a therapeutic target has been evaluated.Gal-3 is widely up-regulated in tumors,and its expression is associated with the development and malignancy of PDAC.In the present study,we demonstrate that a polysaccharide,RN1,purified from the flower of Panax notoginseng binds to Gal-3 and suppresses its expression.In addition,RN1 markedly inhibits PDAC cells growth in vitro,in vivo and in patient-derived xenografts(PDXs).
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