【摘 要】
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O2-delivering nanosystem can initiatively transport O2 into tumors to elevate the sensibility of tumor hypoxic cells to chemoradiotherapy.However,oxygen was difficult to store in those nanosystem long
【机 构】
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The Department of Chemistry,Jinan University,Guangzhou 510632,China
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O2-delivering nanosystem can initiatively transport O2 into tumors to elevate the sensibility of tumor hypoxic cells to chemoradiotherapy.However,oxygen was difficult to store in those nanosystem long time,which would impact the blood circulation time and the accumulation of carried oxygen in tumor result in finally poor effect of tumor therapy.Herein,we designed a novel nanosystem(O2-PIr@Si@PDA)that can act as an oxygen and release oxygen at specific conditions for overcoming hypoxia,which consists of PFOB core for oxygen carrier and functionalized with a novel hypoxia probe(Ir(Ⅲ)complex),subsequently wrapping with silica shell and menthol to seal oxygen,simultaneously coating the polydopamine on the surface of the nanoparticles to realize photothermal conversion.Under NIR irradiation,the nanosystem heated up quickly,so that the oxygen dissolved in PFOB released fastly and PFOB swelled with change of the temperature,resulting in the rupture of the silicon shell and the diffusion of oxygen and Ir(Ⅲ)complex.O2-PIr@Si@PDA multifunctional nanosystem combined with NIR and X-ray could not only improve the inhibition effect of tumor by activating p53-mediated apoptosis in tumor tissue,and can effectively improve tumor hypoxia,but also effectively improve the safety of radiotherapy as a radiotherapy sensitizer.Taken together,this study offers a smart strategy for designing bioinspired tumor-homing nanosystem for precise cancer therapy.
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