【摘 要】
：
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride.We investiga
【机 构】
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Shanghai University of Traditional Chinese Medicine, Shanghai;Shanghai R&D Center for Standardizatio
【出 处】
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第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会
论文部分内容阅读
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride.We investigated the effect of the specific SREBP inhibitor andrographolide, a natural compound isolated from Andrographis paniculata, on the regulation of SREBP signaling by western blot,reporter gene assay and Q-PCR analysis.In addition, the anti-obesity effects of andrographolide were evaluated in C57BL/6 mice with high-fat diet (HFD)-induced obesity.
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