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Diabetic neuropathy is a common complication associated with diabetes and is frequently painful.However,mechanisms responsible for diabetic neuropathic pain are still unclear.Experimental evidence has shown that the galanin and its receptor are involved in pain sensitization.The present study investigated the role of galanin and its receptor system on neuropathic pain in streptozotocin-induced diabetic rats.The effects of galanin, galanin receptor antagonist M35, galanin receptor 1 agonist M617, and galanin receptor 1 agonist AR-M1896 on neuropathic pain were evaluated.The results showed that diabetic rats showed a significant mechanical hyperalgesia between 4 to 12 w.