The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：lisenrui

【摘要】

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【作者】

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Xiaofeng Xu Yunfeng Li Zhenzhong Li

【机构】

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Department of Anatomy, Shandong University School of Medicine, Jinan 250012, China

【出处】

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The 18th Congress of the International Federation of Associa

【发表日期】

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2014年8期

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Diabetic neuropathy is a common complication associated with diabetes and is frequently painful.However,mechanisms responsible for diabetic neuropathic pain are still unclear.Experimental evidence has shown that the galanin and its receptor are involved in pain sensitization.The present study investigated the role of galanin and its receptor system on neuropathic pain in streptozotocin-induced diabetic rats.The effects of galanin, galanin receptor antagonist M35, galanin receptor 1 agonist M617, and galanin receptor 1 agonist AR-M1896 on neuropathic pain were evaluated.The results showed that diabetic rats showed a significant mechanical hyperalgesia between 4 to 12 w.

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The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats

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