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5. Reprogramming mature terminally differentiated adipocytes to induced pluripotent stem cells

Reprogramming mature terminally differentiated adipocytes to induced pluripotent stem cells

来源 :第八届广州国际干细胞与再生医学论坛暨第四届中国再生细胞生物学年会 | 被引量 : 0次 | 上传用户：woyaoqian115

【摘 要】

：

Mature adipocytes are terminally differentiated somatic cells.Here we report the successful generation of induced pluripotent stem(iPS)cells from mouse mature adipocytes by forced expression of six tr

【作 者】

：

Tao Nie Wei Deng Xuefei Gao Wei Sun Xiaoyan Hui Hong Song Dajiang Qin Aimin Xu Peng Li Pentao Liu Liangxue Lai Donghai Wu 

【机 构】

：

Key laboratory of Regenerative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academ

【出 处】

：

第八届广州国际干细胞与再生医学论坛暨第四届中国再生细胞生物学年会

【发表日期】

：

2015年3期

【关键词】

：

adipocyte induced pluripotent stem cell piggyback 

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　　Mature adipocytes are terminally differentiated somatic cells.Here we report the successful generation of induced pluripotent stem(iPS)cells from mouse mature adipocytes by forced expression of six transcription factors(Oct4,Sox2,c-Myc,Klf4,Rarγ and Lrh1)with a piggyBac transposon based strategy.

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