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The Immunological Basis for GVHD The presence of immunocompetent cells in the graft Genetic disparity between donor and recipient The inability of the recipient to reject donor cells The classical Model of the Immunopathogenesis of GVHD Described by Three Interlinked PhasesPro-inflammatory environment Donor T cell proliferation after encountering activated recipient APCs bearing alloantigen Alloreactive cell migration to target tissues and resulting in tissue damage in the form of GVHD