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Objectives To investigate whether curcumin (Cur) suppressed lipopolysaccharide (LPS)-induced inflammation in vascular smooth muscle cells (VSMCs) of rats, and to determine its molecular mechanisms.Methods Primary rat VSMCs were treated with LPS (1 mg/L)and Cur (5, 10 or 30 mmol/L) for 24 h.The levels of MCP-1,TNF-α and iNOS were measured using ELISA and real-time RTPCR.