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The pre-B(o)tzinger complex (pre-B(o)tC) in the ventrolateral medulla oblongata is a presumed kernel of respiratory rhythmogenesis.Ca2+-activated non-selective cationic current is an essential cellular mechanism for shaping inspiratory drive potentials.Ca2+/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ), an ideal 'interpreter' of diverse Ca2+ signals, is highly expressed in neurons in mediating various physiological processes.