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Background:WNT-1 has been demonstrated to play an important role in the carcinogenesis of some cancers,but its significance in oral squamous cell carcinoma (OSCC) has not yet been elucidated.We investigated the WNT-1 expression in OSCC,its role on the expression of beta-catenin and its relation to Ki-67 and tumor differentiation.Materials and Methods:Surgical specimens from 82 OSCC patients were examined for WNT-1,beta-catenin,E-cadherin,gamma-catenin and Ki-67 expression by immunohistochemical staining.The results were compared with the clinicalpathological data and the relationships were correlated.