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Objective:One of the complications of CPB is the systemic inflammatory response syndrome (SIRS).Recent developments tend to minimize the biological impact of CPB in using miniaturized closed circuit with reduced priming volume and less blood-air interface.The benefit of these miniaturized closed circuits in terms of inflammatory response has been proved in coronary surgery.However,in open heart surgery,the CPB circuit is no more closed and the benefit of the miniaturized set-up could disappear.