【摘 要】
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Antibiotics mediate warfare and signaling between organisms, but in most cases, the signaling mechanisms are not well understood.Here we show that exogenous ang
【机 构】
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InstituteofMicrobiology,CAS,Beijing
论文部分内容阅读
Antibiotics mediate warfare and signaling between organisms, but in most cases, the signaling mechanisms are not well understood.Here we show that exogenous angucycline antibiotic,jadomycin B (JdB), acts as an interspecies signal inducing complex survival responses in S.coelicolor at subinhibitory concentration.The receptor for JdB was identified as the previously characterized pseudo GBL receptor, ScbR2, which has the unusual capacity to bind multiple disparate antibiotics.Two additional targets of ScbR2, redDp and adpAp, were identified.
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