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Objective: Nestin is a class Ⅵ intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system development, and is currently widely used in that capacity.Nestin is also expressed in myogenic and other tissue.Increased nestin expression has been reported in various tumors.It is reported to correlate with aggressive growth, metastasis, and poor prognosis in some tumors cells.But the function of nestin has not been cleared completely.We construct nestin transgenic vector and prepare nestin transgenic mice to research the function of nestin.