【摘 要】
：
Chinese reports (1996-2004) of occupational neuropathy in Fujian,Guangdong,Heilongjiang,Henan,Jiangsu,and Liaoning blame environmental contamination of work
【机 构】
：
CenterforResearchonOccupationalandEnvironmentalToxicology,OregonHealth&ScicnceUniversity,USA
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
Chinese reports (1996-2004) of occupational neuropathy in Fujian,Guangdong,Heilongjiang,Henan,Jiangsu,and Liaoning blame environmental contamination of workplace air with n-hexane,the gamma-diketone metabolite (2,5-hexanedione,2,5-HD) of which binds to epsilon-amino groups of lysine,forms pyrrole adducts,and cross-links proteins.We used proteomic methods to identify primary neuroprotein targets of 2,5-HD and its more potent aromatic cousin 1,2-diacetylbenzene (1,2-DAB),both of which induce axonal microtubule segregation and neurofilamentous (NF) axonal neuropathy in rodents.
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