The Role of Sentinel Lymph Node Biopsy in Ductal Carcinoma in Situ

来源 :(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C | 被引量 : 0次 | 上传用户:huangshjing
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  Ductal carcinoma in situ (DCIS), by definition, does not have the ability to travel to axillary lymph nodes and so, in theory, should not require axillary staging.Therefore, when planning surgery in the era of core-biopsy pre-operative diagnosis of screen-detected anomalies we must try to identify the group at highest risk of harbouring invasive disease.Up to 20% of patients with a core biopsy diagnosis of DCIS will harbour invasive disease, consideration of predictors of disease shift, i.e.upstaging of DCIS to invasive carcinoma, should form part of the pre-surgery workup.Silverstein asserts that DCIS is a lesion in which the complete malignant phenotype of unlimited growth, angiogenesis, genomic elasticity, invasion, and metastasis has not been fully expressed.With sufficient time, most non-invasive lesions will develop the ability to invade and metastasise.
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