Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive, cutaneous, malignant tumor characterized by a high propensity for local relapse.Wide and deep local excision with reconstructive surgery is the current standard therapy for DFSP, with a local recurrence rate (LRR) of nearly 40%.In this study, we cured 19 patients with local recurrence of DFSP with 39 sessions of percutaneous cryoablation performed between July 2004and August 2008.The LRRs after one, two and three cryosurgery sessions per patient were 68%, 54% and 0%,respectively.Moreover, the LRR did not differ with tumor location or size.Furthermore, all patients had a progression-free survival of>5 years.Only minor complications such as fever, local edema, mild nerve injury and local pain occurred, and were resolved within 1week with symptomatic treatment.In our experience,percutaneous cryoablation is a relatively safe and efficient technique for the treatment of local recurrence of DFSPs.