【摘 要】
：
Porphyra polysaccharide could exert diverse biological activities such as immunomodulation, antioxidation and antiaging.The purpose of this study was to investigate the neuroprotective effect of porph
【机 构】
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Department of physiology,Medical College of Qingdao University,Qingdao China
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Porphyra polysaccharide could exert diverse biological activities such as immunomodulation, antioxidation and antiaging.The purpose of this study was to investigate the neuroprotective effect of porphyra polysaccharide on 6-OHDA induced cytotoxicity in MES23.5 dopaminergic cells.The results showed that porphyra polysaccharide (1, 10-1, 10-2 mg/mL) alone did not have any toxic effects on MES23.5 cells.Pretreatment with porphyra polysaccharide (1, 10-1, 10-2 mg/mL) could significantly antagonized 25 μmol/L 6-OHDA-induced toxicity to MES23.5 cells, resulting in an increase in cell viability compared with that of 25 μmol/L 6-OHDA solely treated group.However, none of the above doses could antagonize 75 μmol/L 6-OHDA-induced toxicity.The results suggest that porphyra polysaccharide only have partial neuroprotective effect against 6-OHDA-induced toxicity on MES23.5 dopaminergic cells.
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