Apelin, the endogenous ligand of APJ which is a member of G proteincoupled receptors, expressed in a variety of tissues in vivo and involved in the physiological and pathological processes.Studies had shown that apelin/APJ system was involved in the regulation of cardiovascular function, insulin sensitivity and had a close connection with oxidative stress and inflammatory cytokines.Therefore, this article summarized that apelin/APJ system had the effects of inflammationrelated diseases associated with oxidative stress, such as atherosclerosis, hypertension, diabetes and its microvascular complications, ischemiareperfusion injury, tumour and preeclampsia, etc.Meanwhile the drugs targeted apelin/APJ was introduced in order to provide the novel therapeutic strategy for inflammationrelated diseases.