【摘 要】
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Accurate quantification of mRNA in whole blood is made difficult by the simultaneous degradation of gene transcripts and unintended gene induction caused by sample handling or uncontrolled activation
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Accurate quantification of mRNA in whole blood is made difficult by the simultaneous degradation of gene transcripts and unintended gene induction caused by sample handling or uncontrolled activation of coagulation.Incretin peptides, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), possess multiple physiological roles that make them both important peptide biomarkers for metabolic disorder research.Both of these peptides are subject to intrinsic proteolytic degradation and metabolism in human plasma, e.g.by Dipeptidyl Peptidase-IV (DPPIV).Ex vivo stabilization of full length GLP-1 and GIP is critical for their utility in diagnostics and/or drug development.
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