Calumenin-15 facilitates filopodia formation by promoting TGF-β superfamily cytokine GDF-15 transcri

来源 :2013年第四届全国“跨学科蛋白质研究”学术讨论会 | 被引量 : 0次 | 上传用户:hwyvvv
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Filopodia, actin-rich finger-like membrane protrusions, play an important role in cell migration and tumor metastasis.Here, we identify 13 novel calumenin isoforms (calumenin-3 to-15) produced by alternative splicing, and find that calumenin-15 promotes filopodia formation and cell migration.
其他文献
  In proteins, conformational change impacting biological function has been well-investigated in the past decades, which has been generally named allosteric e
会议
  生命活动的很多基本过程是与系统的结构层次密切相关的。较高级的细胞结构层次显示出蛋白质、核酸等生物大分子单独所不具备的生命特征。在较复杂的系统层次上对生物大分
会议
  Arginine methylation plays vital roles in numerous biological processes, such as transcription regulation, RNA processing, DNA repair and signal transductio
会议
  A given protein generally has only one native tertiary fold, which is the conformation with the lowest Gibbs free energy.Mad2, a protein involved in the spi
会议
  Environmental pollution and non-renewable from utilization of fossil energy source which encourage people to explore new energy source.Producing hydrogen us
会议
  A growing number of proteins containing topological knots have been identified over the last few decades.But how such proteins fold remains a mystery.It is
会议
  Curcumin is a novel derivative, safer and more effective for cancer prevention, as we explored previously.However, the advantage of curcumin on cancer treat
会议
  Protein folding, one of the most fundamental events in cells, is very complex and difficult to be characterized in detail.Although much progress, especially
会议
  背景与目的:RhoGD12是RhoGDP解离抑制因子(RhoGDI)家族的主要成员之一,它能够有效的抑制膀胱癌细胞的转移。研究证明,RhoGD12在细胞凋亡过程中,其N端19位置被caspase3酶切
会议
  F-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCF (FBW7) (a complex of SKP1, cullin-1 and FBW7), play
会议