【摘 要】
：
Objective:A, an oral, irreversible ErbB family blocker, was compared with GC in 364 Asian pts with EGFR mut positive NSCLC, including 327 pts from China.PFS was significantly prolonged with A vs GC in
【机 构】
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510080 Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical
【出 处】
：
第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
论文部分内容阅读
Objective:A, an oral, irreversible ErbB family blocker, was compared with GC in 364 Asian pts with EGFR mut positive NSCLC, including 327 pts from China.PFS was significantly prolonged with A vs GC in the overall study population (median 11.0 vs 5.6 months, HR=0.28, P＜0.0001) and Chinese subpopulation (median 11.0 vs 5.6 months, HR=0.30, P＜0.0001).The mature OS data for the Chinese subpopulation in this trial are presented in this abstract.Methods:Treatment-na(o)ve pts were randomized 2∶1 to oral A 40 mg/day or up to 6 cycles of GC (G 1000mg/m2, C 75mg/m2;q21d) and stratified by EGFR mut (De119/L858R/other).
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