【摘 要】
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Objective:Programmed death-1 (PD-1) receptor-ligand interaction inhibits T cell activation against tumor cells.Pembro is a potent and highly selective humanized monoclonal antibody against PD-1 design
【机 构】
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Memorial Sloan Kettering Cancer Center, New York, NY, USA
【出 处】
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第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
论文部分内容阅读
Objective:Programmed death-1 (PD-1) receptor-ligand interaction inhibits T cell activation against tumor cells.Pembro is a potent and highly selective humanized monoclonal antibody against PD-1 designed to directly block its interaction with its ligands, PD-L1 and PD-L2, thus removing the inhibition of T cell activation against cancer.Pembro led to prolonged anti-tumor activity in previously treated NSCLC patients.
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