【摘 要】
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Major depressive disorder (MDD) is a cause of disability that affects approximately 16% of the worlds population, but little is known about the underlying b
【出 处】
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广东省遗传学会第九届代表大会暨学术研讨会
论文部分内容阅读
Major depressive disorder (MDD) is a cause of disability that affects approximately 16% of the worlds population, but little is known about the underlying biology.Evidence from animal, postmortem brain and imaging studies of depressed patients has implicated glial dysfunction in MDD pathophysiology.However, the molecular mechanism through which astrocytes modulate depressive behaviors is largely unknown.Here, we identified adenosine 5-triphosphate (ATP) as a key factor involved in astrocyte modulation of depressive behavior expression in adult mice.ATP is deficient in the brains of mice after social defeated, and ATP administration produced a rapid antidepressant (AD)-like effect.Both a lack of IP3R2 and transgenic blockage of vesicular gliotransmission caused a deficiency of astrocytic ATP release, which produced depressive-like behaviors that were rescued by ATP administration.Furthermore, genetically stimulating endogenous ATP release from astrocytes produced AD-like effects in a mouse model of depression.These results highlight astrocytic ATP release as a biological mechanism of MDD.
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