Targeting INK4 Protein p18INK4c with Small Molecule Inhibitors for Hematopoietic Stem Cell Expansion

来源 :2014天津国际干细胞论坛 | 被引量 : 0次 | 上传用户:kwok916
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Among cyclin-dependent kinase inhibitors (CKIs) that control the G1 phase in cell cycle,only p18 and p27 can negatively regulate hematopoietic stem cell (HSC) self-renewal.
其他文献
How glucose is metabolized can influence cell function,but whether differences in energy metabolism reflect,or dictate,cell state is not clear and is of particular interest given the association of ca
会议
New clinical trial results and the application of deep sequencing have generated new insights into the pathophysiology of severe aplastic anemia (SAA).Eltrombopag,a thrombopoietin mimetic that acts on
会议
Recent efforts in cancer genome sequencing have identified mutations in numerous histone modifying genes,yet the epigenetic mechanisms as a driving force in cancer development remain to be elucidated.
会议
Aplastic anemia (AA) is a rare and severe blood disease.Its incidence varies considerably worldwide,ranging from 4 to 20 per million people.Previous studies have demonstrated that most acquired AA is
会议
Tumor-associated macrophages (TAMs) are widely studied in solid tumors.The distribution of macrophages in lymph node samples was found to be associated with prognosis in lymphomas.
会议
Acute myeloid leukemia (AML) is a hematological malignancy resulting from the transformation of normal hematopoietic stem cell (HSC).Except for the intrinsic factors,it is acceptable that some extrins
会议
Generating engraftable hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) is an ideal approach to get induced HSCs (iHSCs) for regenerative medicine.
会议
The wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) negatively regulates several tumor suppressor and DNA damage response pathways,which have been implicated in stem cell function and aging.
会议
The balance between primitive and mature blood cells is governed by both intrinsic and extrinsic factors.However,this balance can be severely disrupted in disease conditions,such as leukemia.
会议
Cardiac resident stem cells (CSCs) represent a responsive stem cell reservoir within the adult myocardium and recent studies have revealed that CSCs have a significant function in myocardial hemostasi
会议