【摘 要】
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Background Non-alcoholic Fatty Liver Disease (NAFLD), a clinical feature of metabolic syndrome, can develop into serious liver disease such as liver cirrhosis and liver cancer.Recent studies have show
【机 构】
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Xijing Hospital of Digestive Diseases & State Key Laboratory of Cancer Biology, Fourth Military Medi
【出 处】
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The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
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Background Non-alcoholic Fatty Liver Disease (NAFLD), a clinical feature of metabolic syndrome, can develop into serious liver disease such as liver cirrhosis and liver cancer.Recent studies have shown that SIRT1, a highly conserved NAD+-dependent protein deacetylase, can regulate liver lipid metabolism associated proteins, but the detailed mechanism is unknown.Based on approaches of proteomics and functional genomics, using spontaneous occurrence of fatty liver SIRT1-LKO animal model, this study is aimed at screening nonalcoholic fatty liver disease associated molecules, and clarifying how SIRT1 regulates these proteins involved in NAFLD.
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