Grafts loading with heparin have been demonstrated to possess antithrombotic performance.However,the heparin released too fast which did not match the endothelialization rate,resulting in graft occlusion ultimately.Fabrication of core-shell fibrous vascular graft which heparin was encapsulated into the inside of the fibers via coaxial electrospinning became a great choice,and the early research showed partial improvement has been achieved[1,2].