Hydrogen bonded aryI amide and hydrazide foldamers may adopt folded,zigzag or other extended conformations,depending on the positions of the amides and hydrogen bonding sites on the aromatic rings.In recent years,we have developed several series of such preorganized frameworks that can be used as efficient acyclic receptors for binding both neutral and ionic guests.We further find that the aromatic backbones can be readily modified and appended with discrete functional units.Therefore,they are also utilized in designing new molecular tweezers,for assembling ordered supramolecular architectures,and for directing the formation of complicated macrocyclic systems.In the talk,we will present our recent advances.