【摘 要】
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Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of significant economic importance that causes reproductive and respiratory problems in pigs.The replicase non-structural protei
【机 构】
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State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economi
【出 处】
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2013国际猪繁殖与呼吸综合征学术研讨会
论文部分内容阅读
Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of significant economic importance that causes reproductive and respiratory problems in pigs.The replicase non-structural protein 2 (Nsp2) of the porcine reproductive and respiratory syndrome virus (PRRSV) is recognized as the most variable region within the PRRSV genome.This review discusses the molecular characteristics and biological and immunological functions of the PRRSV Nsp2 and its involvement in the viruss pathogenesis.The role of Nsp2 in cell and tissue tropism,replication and growth,and variation and pathogenicity of PRRSV and the differences in virulence among different strains are described in the present review.
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目的 将猪2型圆环病毒(PCV2) ORF2基因重组支气管败血波氏杆菌(Bb),获得能表达猪2型圆环病毒Cap蛋白的减毒支气管败血波氏杆菌,针对猪2型圆环病毒引起的猪多系统功能障碍性疾病,开发一种新型疫苗,利用Bb能在猪呼吸道黏膜上皮细胞有效和有限地定殖并激发黏膜免疫的能力,将PCV2的免疫原性蛋白通过呼吸道途径进行免疫,从而达到预防PCV2的感染,为该重组菌株作为候选疫苗提供科学依据.
GP5,the major glycoprotein of PRRSV,is considered as one possible target of neutralizing antibodies,which however appear only late in infection.This was attributed to the presence of a "decoy epitope"