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  5. RNA interference targeting nucleocapsid protein (N) inhibits porcine reproductive and respiratory sy

RNA interference targeting nucleocapsid protein (N) inhibits porcine reproductive and respiratory sy

来源 :2013国际猪繁殖与呼吸综合征学术研讨会 | 被引量 : 0次 | 上传用户：jonh0521
【摘 要】
：
Background:Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease,which leads to severe economic losses in swine-producing areas of the world.PRRSV ORF7 encodes the
【作 者】
：
M.Yang X.D.Zhang X.Li S.Sylla Z.Ding 
【机 构】
：
College of Veterinary Medicine, and Key Laboratory of Zoonosis Research, Ministry of Education, Inst
【出 处】
：
2013国际猪繁殖与呼吸综合征学术研讨会
【发表日期】
：
2013年12期
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Background:Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease,which leads to severe economic losses in swine-producing areas of the world.PRRSV ORF7 encodes the nucleocapsid (N) protein,which constitutes about 20-40％ of the total protein content of the virion and is essential during the assembly and disassembly of the virion.Currently,the application of RNA interference (RNAi) to the inhibition of PRRSV replication in cell culture becomes a research hotspot,which would become a promising method for the treatment of PRRSV.Based on previous researches and because of the high conservation of PRRSV N gene,we exploit to apply the RNAi technique by targeting N gene to inhibit the PRRSV replication.
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